Buprenorphine Hydrochloride Dosing for dogs, Cats, Horses, Sheep By Weight
Important Safety Information
For dogs: For analgesia, doses may be increased to 0.03-0.04 mg/kg SQ.
For cats: Simbadol concentrated formulation may be administered SQ once daily for up to 3 days.
Use with caution in animals with respiratory depression, liver impairment, or head injuries.
Reference Source
Saunders Handbook of VETERINARY DRUGS, Page 115-117
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Standard Dosage Guidelines
Small Animal Dosage
| Species | Route | Dosage | Frequency |
|---|---|---|---|
| Dogs | IV, IM, SQ | 0.006-0.02 mg/kg | q4-8h |
| CRI | 5 mcg/kg/hour | After 20 mcg/kg IV | |
| Epidural | 0.003-0.006 mg/kg | - | |
| SR | 0.12-0.27 mg/kg | SQ (72 hours) | |
| Cats | IV, IM | 0.01-0.02 mg/kg | q4-6h |
| SQ | 0.24 mg/kg | Once daily for 3 days | |
| Buccal | 0.02-0.04 mg/kg | q8h | |
| CRI | 12 mcg/kg/hour | After 20 mcg/kg IV | |
| Epidural | 12.5 mcg/kg | Diluted to 0.3 mL/kg | |
| SR | 0.12-0.27 mg/kg | SQ (72 hours) |
Large Animal Dosage
| Species | Route | Dosage | Frequency |
|---|---|---|---|
| Horses | IM | 0.005-0.01 mg/kg | Short acting |
| Sheep | IM | 0.01 mg/kg | q6h |