Cyclophosphamide Dosing for Dogs and Cats
Important Safety Information
Monitor for sterile hemorrhagic cystitis. Use with caution in animals with renal impairment or bone marrow suppression.
Regular blood counts and urinalysis recommended during therapy.
Reference Source
Saunders Handbook of VETERINARY DRUGS, Page 218-220
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Standard Dosage Guidelines
Small Animal Dosage
| Species | Route | Dosage | Frequency |
|---|---|---|---|
| Dogs | PO | 2.2 mg/kg | Once daily 4 days/week or q48h |
| PO | 0.3 mg/kg | q24h (metronomic) | |
| IV | 6.8-13.6 mg/kg | Repeat in 21 days | |
| Cats | PO | 6.25-12.5 mg/cat | Once daily 4 days/week |
Additional Protocols
| Protocol | Species | Dosage | Frequency |
|---|---|---|---|
| Pulse therapy | Dogs | 10 mg/kg | Once every 3 weeks |
| Immunosuppressive | Dogs | 2.2 mg/kg | Once daily 4 days/week |
| Metronomic | Dogs | 0.3 mg/kg | q24h continuously |