Dantrolene Sodium Dosing for Dogs, Cats, Horses, Pigs By Weight
Important Safety Information
Note: Doses cited for dogs are from anecdotal experience and extrapolation from humans. Pharmacokinetic studies suggest that these doses are unlikely to produce concentrations high enough to be effective in canine muscle.
Use with caution and monitor for hepatotoxicity.
Reference Source
Saunders Handbook of VETERINARY DRUGS, Page 232-234
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Standard Dosage Guidelines
Small Animal Dosage
| Species | Indication | Route | Dosage | Frequency |
|---|---|---|---|---|
| Dogs | Prevention of malignant hyperthermia | IV | 2-3 mg/kg (up to 5-10 mg/kg) | Single dose |
| Malignant hyperthermia crisis | IV | 2.5-3 mg/kg rapid bolus (up to 5-10 mg/kg) | Single dose | |
| Muscle relaxation | PO | 1-5 mg/kg (up to 5-10 mg/kg) | q8h | |
| Urethral relaxation | PO/IV | 1-5 mg/kg PO or 0.5-1.0 mg/kg IV (up to 5-10 mg/kg) | q8h | |
| Cats | Muscle relaxation | PO | 0.5-2 mg/kg | q12h |
| Relaxation of urethra | PO | 1-2 mg/kg | q8h |
Large Animal Dosage
| Species | Indication | Route | Dosage | Frequency |
|---|---|---|---|---|
| Horses | Muscle relaxation | PO | 4 mg/kg | Single dose |
| Pigs | Malignant hyperthermia | IV | 1-3 mg/kg | Single dose |
| Prophylaxis | PO | 5 mg/kg | Single dose |