Diclazuril Dosing for Horses By Weight
Important Information
For treatment of EPM: 1 mg/kg oral as a top-dress on feed for 28 days added to daily ration.
With repeated administration to steady-state, 0.5 mg/kg body weight achieves a similar pharmacokinetic profile as dosing at the FDA labeled dose of 1 mg/kg.
For prevention of EPM: Top dress feed with pellets: 0.5 mg/kg once every 3 or 4 days.
Reference Source
Saunders Handbook of VETERINARY DRUGS, Page 259-260
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Standard Dosage Guidelines
Small Animal Dosage
No dosing information has been reported for small animals.
Large Animal Dosage
| Species | Route | Dosage | Frequency | Purpose |
|---|---|---|---|---|
| Horses | PO | 1 mg/kg | Once daily for 28 days | Treatment of EPM |
| PO | 0.5 mg/kg | Once daily for 28 days | Treatment of EPM (steady-state) | |
| PO | 0.5 mg/kg | Once every 3-4 days | Prevention of EPM |
Administration Notes
• Administer as a top-dress on feed added to daily ration
• Available as pellets (Clincox, Protazil pellets for horses)
• 0.5 mg/kg achieves similar pharmacokinetic profile as 1 mg/kg with repeated administration to steady-state