Fomepizole Dosing for dogs, Cats, and Large Animals By Weight
Important Safety Information
Fomepizole is used as an antidote for ethylene glycol (antifreeze) poisoning.
Treatment should be initiated as soon as possible after ingestion for best results.
Monitor blood ethylene glycol levels and adjust treatment duration accordingly.
Reference Source
Saunders Handbook of VETERINARY DRUGS, Page 370-371
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Standard Dosage Guidelines
Small Animal Dosage
| Species | Dosage Schedule |
|---|---|
| Dogs | 20 mg/kg initially IV, then 15 mg/kg at 12- and 24-hour intervals, then 5 mg/kg at 36 hours |
| Cats | 125 mg/kg initially, followed by 31.3 mg/kg at 12, 24, and 36 hours after the initial dose. Continue doses every 12 hours until ethylene glycol is no longer detected. If analysis of ethylene glycol is not available, treat with 31 mg/kg every 12 hours through 60 hours |
Large Animal Dosage
| Species | Dosage Schedule |
|---|---|
| Large Animals | No large animal doses have been reported |
Additional Information
Trade Names: 4-Methylpyrazole, Antizol-Vet, and Antizol (human preparation)
Classification: Antidote
Primary Use: Treatment of ethylene glycol (antifreeze) poisoning