Methotrexate Dosing for Dogs and Cats By Weight
Important Safety Information
Methotrexate is a potent anticancer agent with significant side effects. Use only under strict veterinary supervision.
Monitor for bone marrow suppression, gastrointestinal toxicity, and hepatotoxicity. Adjust doses based on individual patient response and toxicity.
Reference Source
Saunders Handbook of VETERINARY DRUGS, Page 538-539
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Standard Dosage Guidelines
Small Animal Dosage
| Species | Route | Dosage | Frequency |
|---|---|---|---|
| Dogs | PO | 2.5-5 mg/㎡ | Every 48 hours |
| IV | 0.3-0.5 mg/kg | Weekly | |
| Cats | PO | 2.5-5 mg/㎡ | Every 48 hours |
| IV | 0.8 mg/kg | Every 2-3 weeks |
Large Animal Dosage
| Species | Route | Dosage | Frequency |
|---|---|---|---|
| No large animal doses have been reported | |||