Neostigmine Dosing for Dogs, Cats, Horses, Cattle, Sheep, Pigs, Ruminants By Weight
Important Safety Information
When used as a treatment for neuromuscular blocking agents (cholinesterase inhibitor), the frequency of administration is determined by clinical response.
Use with caution and monitor for cholinergic effects. Contraindicated in cases of mechanical gastrointestinal or urinary tract obstruction.
Reference Source
Saunders Handbook of VETERINARY DRUGS, Page 587-588
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Standard Dosage Guidelines
Small Animal Dosage
| Species | Route | Dosage | Frequency |
|---|---|---|---|
| Dogs and Cats | PO | 2 mg/kg | Per day in divided doses |
| IM, SQ | 0.01 mg/kg | Antimyasthenic treatment as needed | |
| IM, SQ | 0.04 mg/kg | Antidote for neuromuscular blockade | |
| IM, IV | 0.02-0.04 mg/kg | Diagnostic aid for myasthenia |
Large Animal Dosage
| Species | Route | Dosage | Frequency |
|---|---|---|---|
| Horses | IV, SQ | 0.02-0.04 mg/kg | Frequency determined by clinical response |
| CRI | 0.008 mg/kg/hour | Constant-rate infusion | |
| Cattle | SQ | 0.022 mg/kg | Frequency determined by clinical response |
| Sheep | SQ | 0.022-0.033 mg/kg | Frequency determined by clinical response |
| Swine | IM | 0.044-0.066 mg/kg | Frequency determined by clinical response |
| Ruminants | IM, SQ | 0.02 mg/kg | To stimulate rumen motility |