Prednisolone, Prednisolone Acetate Dosing for dogs, Cats, Horses, Cattle By Weight
Important Safety Information
For dogs: Initial immunosuppressive doses rarely need to exceed 4 mg/kg per day. Always taper dosage gradually for long-term treatment.
For cats: Many conditions require twice the dog dose. Use with caution in animals with diabetes, infections, or gastrointestinal ulcers.
Reference Source
Saunders Handbook of VETERINARY DRUGS, Page 695-697
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Standard Dosage Guidelines
Small Animal Dosage
| Species | Indication | Dosage | Frequency |
|---|---|---|---|
| Dogs | Anti-inflammatory | 0.5-1 mg/kg | q12-24h initially, then taper to q48h at 0.3-0.5 mg/kg |
| Immunosuppressive | 2.2-4 mg/kg | Daily initially, then taper to 2-4 mg/kg q48h | |
| Neurologic disease | 2 mg/kg | q12h for 2 days, then gradual tapering | |
| Replacement therapy | 0.2-0.3 mg/kg | Daily | |
| Cancer therapy | 20-40 mg/m² | 40 mg/m² q24h for 7 days, then 20 mg/m² every other day | |
| Cats | Anti-inflammatory | 1-2 mg/kg | q12-24h initially, then taper to q48h |
| Immunosuppressive | 4.4-8 mg/kg | Daily initially, then taper to q48h | |
| Neurologic disease | 4 mg/kg | q12h for 2 days, then gradual tapering | |
| Replacement therapy | 0.4-0.6 mg/kg | Daily |
Large Animal Dosage
| Species | Indication | Dosage | Frequency |
|---|---|---|---|
| Horses | Prednisolone acetate injection | 100-200 mg | Total dosage IM |
| Prednisolone tablets | 0.5-1 mg/kg | q12-24h PO, taper for long-term treatment | |
| Cattle | Ketosis treatment | 100-200 mg | Total dosage IM |