Propofol Dosing for Dogs, Cats, Horses, Small Ruminants, Pigs By Weight
Important Safety Information
Administer IV slowly over 30-60 seconds. Monitor respiratory and cardiovascular function closely.
Use with caution in animals with cardiovascular disease, respiratory compromise, or hepatic impairment.
For horses: Administer guaifenesin prior to propofol to prevent excitement and myotonus.
Reference Source
Saunders Handbook of VETERINARY DRUGS, Page 710-712
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Standard Dosage Guidelines
Small Animal Dosage
| Species | Route | Dosage | Frequency |
|---|---|---|---|
| Dogs | IV Induction | 3.7-7 mg/kg | Slowly over 30-60 seconds |
| CRI | 5 mg/kg + 100-400 mcg/kg/min | Continuous infusion | |
| Status Epilepticus | 1-6 mg/kg | Followed by CRI 0.1-0.6 mg/kg/min | |
| Cats | IV Induction | 4-8 mg/kg | Slowly, incremental doses as needed |
| CRI | 6 mg/kg + 200-300 mcg/kg/min | Continuous infusion | |
| Short-term | 10-15 mg/kg | Over 1 minute (10-20 min duration) |
Large Animal Dosage
| Species | Route | Dosage | Frequency |
|---|---|---|---|
| Horses | IV | 2 mg/kg | After guaifenesin premedication |
| Small Ruminants | IV | 4 mg/kg | - |
| Pigs | IV | 2-5 mg/kg | - |