Zoledronate Dosing for Dogs, Cats, Horses By Weight
Important Safety Information
Zoledronate must be administered via IV infusion over 15-30 minutes. Do not administer as bolus injection.
Use with caution in animals with renal impairment. Monitor renal function during treatment.
Other bisphosphonates approved for horses include tiludronate and clodronate.
Reference Source
Saunders Handbook of VETERINARY DRUGS, Page 886-887
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Standard Dosage Guidelines
Small Animal Dosage
| Species | Indication | Dosage | Frequency | Instructions |
|---|---|---|---|---|
| Dogs | Standard | 0.2-0.25 mg/kg IV | Every 28 days | Infused over 15 minutes, diluted in saline |
| Osteoporosis | 5 mg total | Every 1-2 years | Fixed dose per dog | |
| Hypercalcemia | 4 mg total | Every 7 days | Cancer-associated hypercalcemia | |
| Multiple Myeloma | 4 mg total | Every 3-4 weeks | Fixed dose per dog | |
| Cats | Standard | 0.2 mg/kg IV | Every 21-28 days | Infused over 15 minutes in 25 mL saline |
Large Animal Dosage
| Species | Indication | Dosage | Frequency | Instructions |
|---|---|---|---|---|
| Horses | Standard | 0.075 mg/kg IV | As needed | Dissolve in citrate solution, mix with saline/mannitol, infuse over 15-30 minutes |